开发先进的电压测量方法用于telmisartan和研究氧化机制在-doped钻石电极
Gustavo Fix1, Ana Heloísa Fonseca Ayala2, Carla Cristina Perez2
1Laboratório de Eletroanalítica e Sensores (LAES), Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, CEP 86057-970, Londrina, PR, Brazil. elensartori@uel.br.
The Analyst
|February 27, 2026
概括
使用添加的钻石电极的新电压计方法可以准确地在各种样本中确定telmisartan (TEL). 这种绿色分析化学方法为telmisartan检测提供了高灵敏度和选择性.
科学领域:
- 分析化学 分析化学
- 电化学 电化学 电化学
- 绿色化学 绿色化学
背景情况:
- 泰尔米沙坦 (TEL) 是一种用于治疗高血压的药物.
- 精确量化TEL对于治疗监测和环境评估至关重要.
- 现有的分析方法可能缺乏灵敏度,选择性或环保性.
研究的目的:
- 开发和验证一种用于测定特尔米沙坦的新型电压测量方法.
- 为了研究telmisartan的电化学氧化机制.
- 评估该方法在现实世界样本中的适用性及其与绿色分析原则的协调性.
主要方法:
- 在电化学分析中,采用预处理钻石电极 (AP-BDDE) 进行电化学分析.
- 微分脉冲电压计 (DPV) 用于定量分析.
- 电化学和核磁共振 (NMR) 光谱学的结合,以阐明氧化机制.
- 方法根据国际指导方针进行验证.
- 在制药,环境和生物样本矩阵中应用.
主要成果:
- 泰尔米沙坦在AP-BDDE上表现出不可逆转的氧化峰值在+1.33V (vs. Ag/AgCl).
- 氧化机制涉及两个电子和两个质子,通过结合的电化学和NMR数据阐明.
- 据DPV证明,TEL的线性在10-109nmol L-1范围内,检测极限低 (0.16nmol L-1).
- 该方法对常见干扰物 (尿液,水) 具有良好的选择性,相对标准偏差<8%.
- 在各种样本类型中成功应用,证实了方法的稳定性.
结论:
- 使用AP-BDDE开发的电压测量方法对telmisartan量化具有敏感性,选择性和可靠性.
- 该研究提供了BDDE上特尔米萨坦的第一个电化学氧化机制.
- 该方法符合绿色分析化学原则,如AGREE评估所示.
- 这种方法为在各种矩阵中对telmisartan进行常规分析提供了一个有前途的工具.
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