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Updated: Feb 28, 2026

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在母乳养期间预测新生儿累积基酸盐暴露量,使用基于生理学的药物动力学建模

Shirley Wang1, Abdullah Hamadeh1, Paola Mian2,3

  • 1School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.

Clinical pharmacokinetics
|February 27, 2026
PubMed
概括

酸 (SB) 通过母乳养对婴儿的传递很小,根据新的儿科生理学基础药理动力学 (PBPK) 模型. 这一发现支持使用SB治疗尿素循环障碍的母亲继续母乳养.

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