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识别额外的DPYD多态,增加严重甲胺毒性风险,并提高预测准确性,当与先前验证的变体结合时

Nam Nguyen-Hoang1, Kelly Nugent1, Sophia Jaso1

  • 1University of Michigan-Ann Arbor Ann Arbor United States.

Clinical cancer research : an official journal of the American Association for Cancer Research
|February 27, 2026
PubMed
概括

识别不常见的DPYD基因变异可以帮助预测胺 (FP) 化疗毒性. 测试这些变体可以改善风险预测,允许调整剂量以防止高风险患者发生严重不良事件.

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