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基于有机J-聚合物的NIR激活的杀菌-抗氧化微针,以加速受感染的伤口愈合

Zhijun Wang¹, Xiaohuan Wang², Jiakun Song²

¹Department of Chemistry, Changzhi University, Changzhi 046011, P. R. China.

ACS applied bio materials

|February 27, 2026

概括

一种新的近红外激活纳米组件 (BC@P) 为受感染的伤口提供了双重杀菌和组织修复功能. 这个"杀死和修复"平台利用J聚合来增强近红外吸收和高效的伤口愈合,同时具有生物安全性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
医疗器械医疗器械

背景情况:

细菌感染的伤口需要及时治疗,以防止严重的并发症.
目前的疗法往往缺乏对细菌根除和组织再生的双重功能.

研究的目的:

开发一种近红外 (NIR) 激活的纳米组件 (BC@P),具有结合的杀菌和组织修复能力.
为了研究BC@P集成到微针贴片中的疗效,用于感染伤口的治疗.

主要方法:

通过B(TIBC) 2 ,黄素和8臂PEG的自组装来制造BC@P.
描述BC@P的光热,抗氧化和NIR-II发射特性.
在受感染的伤口模型中评估BC@P装载微针贴片的性能.

主要成果:

BC@P表现出广泛的NIR吸收,高光热转换效率 (53.1%) 和强大的抗氧化能力.
纳米组件有效地根除了细菌,调节了炎症,并在体内加速了伤口愈合.
微针贴片促进了有效的皮肤透和治疗,具有出色的生物安全性.

结论:

BC@P是一个有前途的"杀死和修复"平台,用于治疗细菌感染的伤口.
该研究为设计生物NIR-II成像和治疗应用的J聚合物支架提供了一个范例.

关键词:

在J-聚合物.激活的NIR已被激活这是一种抗炎症药物.抗菌平台是一种抗菌平台.微针微针是一种微针.光热反应的光热反应

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