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鼻内胰岛素治疗嗅觉功能障碍的有效性:系统性审查
ORL; journal for oto-rhino-laryngology and its related specialties
|February 27, 2026
概括
鼻内胰岛素 (INI) 显示出改善嗅觉功能的承诺,对于嗅觉丧失的人来说. 需要进一步的研究来确认其有效性,并为这种嗅觉功能障碍治疗制定临床指南.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 嗅觉功能障碍 (OD) 影响患有阿诺斯米亚和/或低的患者.
- 目前OD的治疗选择有限.
- 鼻内胰岛素 (INI) 正在作为一种潜在的治疗剂进行研究.
研究的目的:
- 系统地审查鼻内胰岛素 (INI) 治疗嗅觉功能障碍 (OD) 的有效性和安全性.
- 在患有嗅觉障碍的患者中,比较INI与安慰剂或不治疗的疗效.
主要方法:
- 在Medline,Scopus,DOAJ和Springer自然期刊中进行系统的文献搜索.
- 研究协议注册于PROSPERO (ID:CRD42023456891) 并根据PRISMA指南进行设计.
- 纳入标准:年龄在18岁以上的参与者患有低血或无血;排除标准:由于特定的解剖学,创伤,神经退行性,手术或损伤相关原因导致的OD.
主要成果:
- 包含了五项研究,共有131名参与者 (63名男性,68名女性;年龄16-56岁).
- 大多数研究使用了40 IUINI剂量;一项研究使用了多种剂量.
- 所有研究都报告了INI给药后嗅觉功能的改善;在一些研究中观察到微小的葡萄糖水平波动.
结论:
- 鼻内胰岛素 (INI) 似乎是嗅觉功能障碍 (OD) 的有效治疗方法.
- 建议进一步进行高质量的临床试验,以巩固INI在OD治疗中的临床建议.
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