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Updated: Mar 1, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
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Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

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寡合化使小分子能够选择性地准一个内在无序的区域

Stasė Bielskutė-García1, Borja Mateos1, Muhammad Awawdy2

  • 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain.

Science advances
|February 27, 2026
PubMed
概括

小分子可以通过与其结构化的寡合体形式结合来选择性地准内在无序区域 (IDR),而不仅仅是单体. 这一发现为针对这些具有挑战性的蛋白质区域提供了新的治疗策略.

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