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Updated: Mar 1, 2026

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
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Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis

Published on: April 16, 2018

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转录因子属性的全球地图揭示了基于值的DNA结合和移动集群的形成

Sadia Siddika Dima1, Meghan A Turner2, Hernan G Garcia2,3,4,5,6

  • 1Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.

Science advances
|February 27, 2026
PubMed
概括

转录因子度,特别是Drosophila胚胎中的Dorsal (Dl),影响DNA结合和集群形成. 这项研究揭示了新的Dl集群及其与度值的联系,这表明在基因调节中存在液态-液态相分离.

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

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Transcription Factors02:16

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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