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Updated: Mar 1, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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基于PROTAC的合成杀伤性策略内源地激活系统性STING,以提高抗瘤免疫力

Ye Liu1, Maolin Jiang1, Mengchao Ding1

  • 1School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, P.R. China.

Science advances
|February 27, 2026
PubMed
概括

用PROTACs准DNA修复会降解PARP1和BRD4,从而诱导合成致命性. 这种方法增强了STING通路的激活,以获得由NK和T细胞介导的强有力的抗瘤免疫力.

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