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Updated: Mar 1, 2026

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与STAT5相比,构成性STAT3信号增强了CAR T细胞的疗效,并降低了全身毒性

Haosong Zhang1, Yusuke Ito1, Hitomi Kasuya1

  • 1Keio University Tokyo Japan.

Cancer immunology research
|February 27, 2026
PubMed
概括

在仿真抗原受体 (CAR) T 细胞中激活STAT3,增强了抗瘤效果并降低了毒性,而STAT5则促进了增殖,但导致了全身性问题. 选择性STAT3激活为改善CAR T细胞治疗提供了一个有希望的策略.

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