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Updated: Mar 1, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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针对性蛋白质降解作为一种新的治疗策略来对抗传染病

Lyn-Marié Birkholtz1, Tiaan Olivier2, Tyrick Welcome3

  • 1Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa; Africa Centre for Therapeutics Innovation, Stellenbosch University, Stellenbosch, South Africa; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

Current opinion in chemical biology
|February 27, 2026
PubMed
概括

向蛋白质降解 (TPD) 提供了一种新的抗菌方法,通过使用向蛋白质溶解的奇默体 (PROTACs) 来降解病原体. 这一战略对抗结核病和疟疾等耐药性感染具有前景.

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