相关实验视频

Updated: Mar 1, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

帕金森病的体力表现和肉症的临床相关性:一个横截面研究

Samuel Brito de Almeida¹, Danielle Pessoa Lima^2,3, João Rafael Gomes de Luna²

¹Universidade Federal do Ceará, Hospital Univerisátio Walter Cantídio, Unidade de Pesquisa Clínica, Fortaleza CE, Brazil.

Arquivos de neuro-psiquiatria

|February 27, 2026

概括

帕金森病患者的SARC-F得分高,姿势不稳定和步行困难 (PIGD) 显示身体表现较差. 这些因素有助于识别有功能衰退风险的个体.

科学领域:

神经学神经学
老年学是指老年学的学科.
康复科学康复科学康复科学

背景情况:

帕金森病 (PD) 通过运动和非运动症状显著影响生活质量.
确定身体表现的临床预测因素对于管理PD患者至关重要.
肌肉损失的状况 - - 萨科佩尼亚 - - 在老龄化人口和神经退行性疾病中越来越多地被发现.

研究的目的:

研究患有轻度至中度帕金森病 (PD) 个体的肉类症指标和身体表现之间的关联.
确定预测PD患者身体表现不佳的临床因素.
评估SARC-F问卷和Ishii评分对评估PD相关功能衰退的有用性.

主要方法:

在127名患有轻度至中度PD (Hoehn & Yahr I-III阶段) 的患者进行了横截面研究.
使用短物理性能电池 (SPPB) 评估的身体性能.
使用SARC-F问卷,Ishii分数,手握强度和DXA对身体组成和尾肌肉质量进行评估.

主要成果:

39%的PD患者表现出低体力表现.
阳性SARC-F查 (≥4) 与身体表现不佳 (OR: 1.67) 有着强烈的关联.
姿势不稳定和步行困难 (PIGD) 和SARC-F得分是身体表现不佳的独立预测指标,组合模型显示出良好的区分精度 (AUC = 0.82).

结论:

较高的PIGD分数和SARC-F分数与PD的体力表现下降有关.
SARC-F和Ishii分数可以帮助识别患有功能衰退风险的PD患者.
需要进一步的纵向研究来确定因果关系并为治疗策略提供信息.

更多相关视频

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

相关概念视频

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.