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Updated: Mar 1, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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新辅助剂Fc增强的抗CTLA-4向Tregs增强高风险前列腺癌的雄激素缺乏:一个随机的第一阶段试验

Casey R Ager1, Aleksandar Obradovic2, Patrick McCann3

  • 1Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Immunology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA; Department of Urology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.

Cell reports. Medicine
|February 27, 2026
PubMed
概括

新辅助性抗雄激素剥夺疗法加上一种阿福可赛化抗CTLA-4抗体是高风险前列腺癌 (PCa) 的安全和可行的. 这种组合疗法减少了瘤透调节性T细胞 (TI-Tregs),增强了抗瘤免疫反应.

关键词:
在 CTLA-4 中.赛托夫 (CyTOF) 是一种树突细胞是一种树突细胞.新辅助免疫疗法新辅助免疫疗法前列腺癌是前列腺癌.监管T细胞的监管性T细胞一个单细胞RNA测序.与瘤相关的巨细胞.

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