网络向的TMS调节了尼古丁渴望和默认模式网络连接在精神疾病中
Heather Burrell Ward1, Sophia H Blyth1, Simon Vandekar2
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Brain stimulation
|February 27, 2026
概括
在患有精神病的人群中,改变的默认模式网络 (DMN) 连接与吸烟有关. 通过跨膜磁性刺激 (TMS) 参与DMN,降低了尼古丁渴望,这表明了新的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 烟草使用是精神分裂症中早期死亡的主要可预防原因.
- 以前的研究表明,尼古丁可能会使精神分裂症的默认模式网络 (DMN) 失调正常化.
- 在精神病谱系障碍中,DMN组织和烟草使用之间的确切关系需要进一步研究.
研究的目的:
- 为了验证DMN连接和烟草使用之间的关联在一个大精神病频谱样本中.
- 为了研究DMN向的跨膜磁性刺激 (TMS) 单次和多次会话对尼古丁渴望的影响.
主要方法:
- 利用双极精神分裂症网络中介表型2 (B-SNIP2) 研究 (n=596) 的数据来研究与烟草使用有关的DMN连接性.
- 进行了两项TMS研究:一个是单一会话 (iTBS,cTBS,sham),另一个是加快,多会话cTBS (5会话) 在患有精神病的人身上.
- 在TMS干预之前和之后评估神经影像和尼古丁渴望.
主要成果:
- 在B-SNIP2样本中,当前吸烟者与以前和从未吸烟者相比,表现出较低的DMN连接性.
- 单次会话的iTBS (间歇性甲突破刺激) 意外地增加了渴望,而cTBS (连续的甲突破刺激) 没有显著的影响.
- 加速,多会话DMN向的cTBS显著减少了每个会话后的渴望,并减少了DMN连接.
结论:
- 确定了一种潜在的机制,将精神病中的尼古丁使用与DMN组织联系起来.
- 针对DMN的TMS,特别是多会话cTBS,在减少尼古丁渴望方面显示出有前途.
- 这项研究表明,在患有精神病的个体中,解决尼古丁依赖症的新治疗目标.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.9K
07:12Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
4.3K
相关概念视频
01:27CNS Depressants: Alcohol and Nicotine
1.4K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.4K
01:14Brain Imaging
799
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
799
01:23Drugs Acting on Autonomic Ganglia: Stimulants
2.2K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.2K