鼻腔布德索尼德可减轻过敏鼻炎成年人空气污染的影响:一项随机试验
Eashan Halbe1, Christopher F Rider1, Agnes C Y Yuen1
1Air Pollution Exposure Laboratory, Division of Respiratory Medicine, Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
概括
鼻腔布德索尼德喷雾剂减少了过敏性鼻炎的炎症,并在暴露于过敏原和柴油废气 (DE) 后改变了鼻腔表观遗传衰老加速 (EAA). 这种治疗改善了过敏性鼻炎患者的鼻气流和症状.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 过敏性鼻炎 (AR) 是一种常见的疾病,涉及由空气中的过敏原引发的鼻炎.
- 鼻腔皮质类固醇 (NCS) 是一种标准的AR治疗方法,但其在柴油废气 (DE) 暴露后的有效性和对鼻腔表观遗传衰老加速 (EAA) 的影响尚不清楚.
研究的目的:
- 评估鼻腔布德索尼德对AR相关鼻炎的作用.
- 为了研究鼻腔布德索尼德在DE暴露后对鼻腔EAA的影响.
主要方法:
- 一个双盲随机交叉试验,涉及20名健康AR患者.
- 参与者接受了布德索尼德或安慰剂鼻喷雾,随后是过敏原和DE暴露.
- 测量了鼻腔细胞因子,EAA,鼻腔气流 (PNIF) 和症状得分 (TNSS).
主要成果:
- 布德索尼德治疗前减少了暴露后的鼻腔IL-5和IL-17A水平.
- 鼻腔布德索尼德改善了PNIF,并抑制了过敏原诱导的TNSS.
- 布索尼德治疗和过敏原/DE暴露都影响了鼻腔EAA.
结论:
- 预防性鼻腔布德索尼德有效降低了AR患者的鼻腔炎症.
- 鼻腔布德索尼德调节了鼻腔EAA,并在过敏原和DE暴露后改善了鼻腔气流.
- 这些发现凸显了布德森在控制AR症状和相关表观遗传变化的作用.
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