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Updated: Mar 1, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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在 Sin3A PAH1 αα-hub 域中的稳定性和相互作用缺陷与功能变异的丧失相关

Amanda D Due1, Sigrid Jørsboe2, Louise T Jensen2

  • 1REPIN, University of Copenhagen, Copenhagen, Denmark; Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark; Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

The Journal of biological chemistry
|February 27, 2026
PubMed
概括

像Sin3A这样的枢纽蛋白对于细胞相互作用至关重要. 这项研究揭示了Sin3A-PAH1域中的突变如何影响其稳定性和结合性,影响Witteveen-Kolk综合征.

关键词:
国内发展计划 (IDP) 是一个.这是一个IDR IDR.疾病 疾病 疾病 疾病蛋白质领域 蛋白质领域蛋白质折叠 蛋白质的折叠蛋白质与蛋白质的相互作用这种侧链变体是侧链变体.结构-功能的结构-功能.转录的核心调节器

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