带有鼻息肉的eosinophilic慢性鼻炎:状甲形成作为一个相关的重塑特征
Shaobing Xie1, Sijie Jiang1, Junyi Zhang1
1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China; Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China; National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
状元是一个常见的特征eosinophilic慢性鼻炎与鼻 (eCRSwNP). 干白素-4/13 (IL-4/13) 信号驱动这种变化,杜皮卢马布可以减少这种变化,帮助上皮质修复.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 表皮重塑对于带有鼻的eosinophilic慢性鼻炎 (eCRSwNP) 的核心作用.
- 状元形成是CcRSwNP上皮层重塑的一个未被认可的方面.
研究的目的:
- 为了确定在CcRSwNP中形形质形成的流行率.
- 为了研究驱动eCRSwNP中的状元形成的分子机制.
- 评估IL-4/13和dupilumab对表皮性转化症的影响.
主要方法:
- 对844个具有鼻息肉 (CRSwNP) 标本的慢性鼻炎组织学审查.
- 用RNA测序和RT-qPCR进行基因表达分析.
- 在体外用IL-4/13和dupilumab刺激的空气液体接口 (ALI) 培养物.
主要成果:
- 在CRSwNP的15.6%中发生了状代谢,CRSwNP (25.7%) 显著高于非生性 (neCRSwNP) 亚型 (7.5%).
- 在eCRSwNP组织中,氨酸细胞分化标志物 (KRT6A,KRT13,FLG,p63,Ki67) 的升高.
- 在体外,IL-4/13诱导了状变化,而dupilumab治疗减弱了这种变化.
结论:
- 状元是一个普遍的,低估的特征在eCRSwNP.
- IL-4/13信号传递是这种病态上皮层重塑的关键驱动因素.
- 杜皮卢马布通过减轻这些变化来恢复上皮质平衡的潜力.
相关概念视频
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:


