加快的生物衰老和中风和痴呆的动态转变:多状态轨迹分析
Wenke Cheng1, Liuyu Chen2, Pinfang Kang1
1Department of Cardiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Neurobiology of disease
|February 27, 2026
概括
加快的生物衰老 (BAA) 增加了初始中风,痴呆和死亡的风险. 然而,BAA在这些诊断后没有显著预测进展到并发症.
科学领域:
- 老年学和衰老研究研究.
- 神经科学和神经病学 神经科学和神经病学
- 公共卫生和流行病学
背景情况:
- 加快的生物衰老 (BAA) 与与年龄有关的疾病的易感性增加有关.
- 在神经血管疾病的进展中BAA的具体作用尚不清楚.
研究的目的:
- 通过KDM-BA和PhenoAge算法估计的BAA对中风,痴呆,并发症和死亡率的顺序发展的影响.
- 为了评估BAA和疾病过渡在一个大队列之间的关联.
主要方法:
- 利用了来自220236名没有先前中风或痴呆症的参与者的英国生物库数据.
- 使用克莱梅拉-双方法计算的BAA-生物年龄 (KDM-BA) 和表型年龄 (PhenoAge).
- 采用多州考克斯模型,分析五个州的八种疾病转变:基线,中风,痴呆,并发症和死亡.
主要成果:
- 每一个BAA标准偏差的增加都与较高的初始中风,痴呆和死亡风险显著相关.
- PhenoAge加速显示,中风 (1.16),痴呆 (1.10) 和死亡 (1.24) 的风险增加.
- 对于从中风或痴呆症到并发症的过渡,没有发现任何显著的关联,在时间间隔和子组中一致.
结论:
- BAA与中风,痴呆和死亡率的初始发作有关.
- 在初始诊断后,BAA与进展至并发症的关联并不明显.
- BAA对于早期识别与年龄有关的疾病的脆弱性和指导预防性干预可能是有价值的.
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