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Updated: Jun 28, 2026

Reservoir Condition Pore-scale Imaging of Multiple Fluid Phases Using X-ray Microtomography

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Published on: February 25, 2015

了解平板电脑中的实时水透动态,使用同步龙X射线微型计算机断层扫描

Denis Kalugin¹, Prajwal Thool², Carter Blocka¹

¹Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, Saskatchewan, S7N 5A9, Canada.

Journal of pharmaceutical sciences

|February 27, 2026

概括

平板电脑的水透是药物释放的关键. 诸如酸 (MgSt) 和十字糖 (CCS) 等辅助剂的特性显著影响水的吸收和药片分解,影响药物的生物可用性.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
生物物理学的生物物理.

背景情况:

了解药物片中的水透对于药物的生物可用性至关重要.
控制初始水吸收的微观结构机制仍然不太清楚.

研究的目的:

为了可视化和量化水透过程中药片中的微观结构变化.
阐明常见的制药辅助剂在水透动态中的作用.

主要方法:

使用现场同步龙X射线微型计算机断层扫描 (X射线μCT).
分析了由微晶纤维素 (MCC),酸 (MgSt),二酸 (DCP) 和交叉酸盐 (CCS) 组成的药片.

主要成果:

酸 (MgSt) 的疏水性显著阻碍了微晶纤维素 (MCC) 片中的水透.
结合膨胀MCC与刚性二酸 (DCP) 加快了由于协同孔隙扩张的水透.
交叉粉 (CCS) 诱导了快速碎片化和高孔度 (<3秒).

结论:

药片水的透是由多种多样的协同机制控制的,包括辅助剂的胀,刚性和碎片化.
辅助剂的特性极大地影响了水的透动态和毛孔网络的稳定性.
这些见解对于设计可改善药物生物利用性的口服固体剂型至关重要.

关键词:

3D非侵入性成像 3D非侵入性成像微观结构的微观结构药物药片药物药片药物药片同步光X射线微型计算机断层扫描 (μCT)水的透透水的透

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