增加的C-反应蛋白和未能在儿科狼性炎中实现缓解:一个回顾性队列研究
Jia Zhang1, Hongye Wang, Xuemei Jiang
1Department of Nephrology & Rheumatology, Kunming Children's Hospital (Affiliated to Kunming Medical University), Kunming, Yunnan, China.
Medicine
|February 27, 2026
概括
升高的C-反应蛋白 (CRP) 与儿童狼性炎 (LN) 治疗结果不佳有关. 监测CRP可能有助于预测LN的儿科患者的缓解失败.
科学领域:
- 儿科脏病学 儿科脏病学
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
背景情况:
- 狼性炎 (LN) 显著恶化了系统性红斑狼儿童的结果.
- 儿科LN短期治疗成功的预测因素尚未得到充分证实.
- 炎症标记在管理自身免疫性疾病 (如LN) 中至关重要.
研究的目的:
- 确定与诊断为LN的中国儿童治疗缓解相关的因素.
- 研究炎症标志物,特别是C反应蛋白 (CRP) 在预测缓解中的作用.
- 评估包含CRP的nomogram对预测缓解状态的有用性.
主要方法:
- 72名患有LN的儿童 (0-18岁) 的回顾性队列研究.
- 部分缓解定义为蛋白尿减少和稳定的估计球过率 (eGFR).
- 用单变量和多变量考克斯回归分析来确定缓解失败的风险因素.
主要成果:
- 基线C-反应蛋白 (CRP) 水平升高与儿科LN患者无法实现缓解显著相关.
- 多变量分析证实CRP是短期缓解失败的独立风险因素 (HR 1.075,P=.008).
- 整合CRP的诺米图显示了适度的区分能力 (AUC=0.739) 来预测24周后的缓解.
结论:
- 基线CRP是儿科狼神经炎短期缓解失败的独立预测因子.
- 监测CRP水平可能有助于指导临床干预和评估儿科LN的治疗反应.
- 这些发现强调了炎症标志物在治疗儿童LN中的重要性.
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