患有原发性副甲状腺功能障碍的成年人患结石的危险因素:系统审查和元分析的方案
Mohammad Jay1, Sorina Andrei2, Peter Hoang3
1Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada mohammad.jay@mail.utoronto.ca.
BMJ open
|February 27, 2026
概括
这项研究调查了原发性副甲状腺症 (PHPT) 中结石的危险因素. 识别这些因素对于管理PHPT并发症和改善患者结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医学研究方法学 医学研究方法学
背景情况:
- 原发性副甲状腺功能障碍 (PHPT) 涉及副甲状腺过度活跃和不平衡.
- 结石 (RS) 是PHPT已知的并发症,导致显著的发病率.
- 在PHPT中RS的风险因素尚未得到充分确定,这突显了研究缺口.
研究的目的:
- 系统地审查和对初级甲状腺功能障碍症成年人结石风险因素的证据进行元分析.
- 解决国际指导方针中关于PHPT中结石风险的研究重点.
主要方法:
- 一个符合PRISMA标准的系统审查和元分析协议.
- 在MEDLINE,EMBASE和Cochrane控制试验中央注册表中进行搜索.
- 包括前性/回顾性队列,病例控制和横截面研究;排除RCT,病例报告,评论和摘要.
- 独立的数据提取和偏差风险评估,使用预测研究的质量工具.
- 使用随机效应模型将调整和未调整的赔率比率组合在一起.
- 用I2统计评估异质性,用GRADE评估证据确定性.
主要成果:
- 研究方案概述了识别和分析预先规定的风险因素的方法.
- 需要调查的关键危险因素包括年龄,性别,尿路,血清,血清副甲状腺激素和血清25-基维生素D.
- 分析将提供关联的综合估计,并评估证据的确定性.
结论:
- 这一系统性审查和元分析将提供关于初级甲状腺功能障碍症中结石风险因素的证据的综合总结.
- 预计这些发现将为临床实践提供信息,并指导未来管理PHPT的研究优先事项.
- 传播将通过同行评审的出版物和会议演讲进行.
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