肝脏免疫状况指数与肝硬化患者的营养状况和预后的关联
Ryota Yoshioka1, Takashi Nishimura1, Naoto Ikeda1
1Department of Gastroenterology, Hyogo Medical University, Nishinomiya, Japan.
In vivo (Athens, Greece)
|February 27, 2026
概括
肝脏免疫状况指数 (LISI) 反映了肝硬化严重程度和营养不良. 肝硬化患者的LISI得分较高表明肝功能较差,预后更差,突出其临床相关性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 临床营养学 临床营养学
背景情况:
- 肝硬化与免疫功能受损有关,导致不良的临床结果.
- 评估肝硬化患者的免疫状况在临床上具有挑战性.
- 肝免疫状况指数 (LISI) 是为了估计肝细胞癌的肝切除术后的免疫状况而开发的.
研究的目的:
- 研究LISI与肝功能,营养状况和肝硬化患者的预后之间的关联.
主要方法:
- 对319名肝硬化患者进行间接热量计以进行营养评估的分析.
- 评估LISI值与肝功能参数,营养状况和预后之间的相关性.
主要成果:
- LISI值与疾病严重程度,Child-Pugh和白蛋白-白素 (ALBI) 评分正相关.
- LISI与老年人营养风险指数 (GNRI) 呈现逆相关性,蛋白质和能量营养不良的患者中较高.
- 与LISI值较低的患者相比,LISI值较高的患者呈现出较差的预后.
结论:
- 在肝硬化患者中,LISI与肝纤维化的严重程度,肝功能下降和营养不良有关.
- 升高的LISI值表明该人群的预后不佳.
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