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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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抗CD146自身抗体:第一种与系统性硬化症职业暴露相关的生物标记物.

Julien Bermudez1, Xavier Heim2, Elise Kaspi3

  • 1Aix Marseille Univ, APHM, INSERM, INRAE, C2VN, Hôpital Nord, Department of Respiratory Medicine, Marseille, France.

ACR open rheumatology
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概括

对CD146的自身抗体 (AACD146) 在全身性硬化症 (SSc) 患者中被检测到,特别是男性职业暴露. 这些发现将AACD146确定为与环境因素相关的SSc的潜在生物标志物.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 自免疫性疾病 自免疫性疾病
  • 职业健康 职业健康 职业健康

背景情况:

  • 系统性硬化症 (SSc) 是一种严重的自身免疫性疾病.
  • 职业暴露是SSc.的重要危险因素.
  • CD146通过Wnt/ROS通路调节SSc中的纤维化.

研究的目的:

  • 调查CD146是否是SSc.自身免疫的目标.
  • 开发和验证一种检测抗CD146自身抗体的方法 (AACD146).

主要方法:

  • 开发了一种用于检测AACD146的内部ELISA,通过免疫沉和西式斑点检测得到确认.
  • 在SSc患者和健康对照中评估了AACD146.
  • 与癌症患者和未暴露的对照人群相比,一组暴露于石棉/的工人的验证结果.

主要成果:

  • 在SSc患者 (15%) 中,AACD146的流行率明显高于对照组 (5%).
  • 在SSc患者中,AACD146阳性与男性性别和暴露相关 (敏感度为57%,特异性为88%).
  • 验证队列在职业暴露个体中显示57%的AACD146阳性,明显高于对照组和癌症患者.

结论:

  • AACD146在SSc患者中可检测,并且与男性的职业粉尘暴露有关.
  • AACD146代表了第一个将职业暴露与SSc.联系起来的生物标志物.
  • 这些生物标志物可能对SSc.的预防医学有影响.