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在美国,炎症性肠病的生物剂量升级
Casey Chapman1, Aisha Vadhariya2, Nicholas Bires2
1GI Alliance, Baton Rouge, LA.
近三分之一的炎症性肠病 (IBD) 患者升级了生物疗法,显著增加了医疗保健成本. 这突显了IBD长期管理的挑战,以及需要具有成本效益的生物策略.
科学领域:
- 胃肠病学 胃肠病学
- 药物经济学 药物经济学
- 临床药房 临床药房
背景情况:
- 生物药物对于管理炎症性肠病 (IBD) 至关重要,包括克罗恩病 (CD) 和性结肠炎 (UC).
- 终身疾病进展和潜在的响应丧失需要治疗调整,例如生物剂量升级.
- 了解剂量升级对治疗结果和成本的影响对于优化患者护理至关重要.
研究的目的:
- 为了确定CD和UC患者生物剂量升级的频率.
- 评估剂量升级对IBD管理中的医疗保健支出的影响.
主要方法:
- 在2017年1月至2022年6月期间,对成人CD和UC患者进行生物药物 (adalimumab,infliximab,ustekinumab, vedolizumab,tofacitinib) 的回顾性分析.
- 在12个月的随访期内评估剂量升级,停止和切换模式.
- 在指数生物治疗期间计算每患者每月 (PPPM) 的IBD相关医疗保健费用.
主要成果:
- 剂量升级发生在CD和UC患者中约30%的患者中,具体生物药物之间存在差异.
- 经过剂量升级的患者的停药率较低,但随后的生物转换率更高.
- 与PPPMIBD相关的平均成本是相当大的,从4,543美元到14,246美元不等,剂量升级是增加成本的重要预测因素.
结论:
- 生物剂量升级在IBD中很常见,并显著提高与疾病相关的医疗保健成本.
- 这些发现强调了IBD长期生物治疗的复杂性.
- 对优化生物管理策略的进一步研究对于改善患者的治疗结果和控制成本至关重要.
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