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Updated: Mar 1, 2026

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TRIM13在现场工程增强了CAR-Ms的抗炎能力,用于肝纤维化治疗

Jinxin Gao1, Zhenmei Yang1, Yudong Song1

  • 1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Comprehensive Health Frontier Sub-Center of Interdisciplinary Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.

Nature communications
|February 27, 2026
PubMed
概括

使用TRIM13的工程CAR-T细胞增强抗炎性质,通过向FAP和解决炎症来改善肝纤维化治疗. 这种方法可以提高治疗效果和恢复肝功能.

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