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Updated: Mar 1, 2026

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通过类酸抗意义寡核化物对DNA损伤反应的调节失调

Linn Hjelmgren1, Qianyu Zhou1, Sandro Schmidli1

  • 1Department of Oncology and Pathology, Karolinska Institutet, Solna, Sweden.

Nature communications
|February 27, 2026
PubMed
概括

反感性寡核酸 (ASOs) 可以通过与修复酶形成核凝结物来触发有害的DNA损伤反应. 这一发现揭示了ASO毒性和异常DNA修复激活的机制.

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