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可视化分子扩散方向和固体状态中的过程,通过二色光共结晶转换

Jialu Zheng¹, Xiwen Zhu¹, Wei Wang¹

¹Key Laboratory of Biomedical Analytics, Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, People's Republic of China.

Nature communications

|February 27, 2026

概括

这项研究使用电荷转移光可视化了固态分子运动 (SSMM),揭示了意想不到的扩散差异. 这使得敏感的杂质检测和实时反应监测成为可能.

科学领域:

材料科学材料科学材料科学
超分子化学超分子化学
化学物理化学物理

背景情况:

固态分子运动 (SSMM) 对材料特性至关重要,但难以可视化.
了解SSMM动态 (方向,速度) 是释放其全部潜力的关键.
现有的方法缺乏详细说明SSMM机制的解决方案.

研究的目的:

开发一种在共晶系统中可视化和调节SSMM的方法.
阐明SSMM的详细动态,包括扩散速率和方向.
为了证明杂质分析和反应监测中的应用.

主要方法:

使用了分子间电荷转移 (ICT) 介导的光策略.
采用了由6-甲基-2-乙甲 (MA) 和1,2,4,5-四亚 (TCNB) 组成的二进制共晶系统.
利用可逆相变换 (MA/TCNB=1/1和MA/TCNB=1/2) 通过二色光实现实时可视化.

主要成果:

实现了SSMM动态的实时可视化,使用局部化的二色光签名.
观察到MA和TCNB之间扩散率的显著差异,包括单向扩散.
证明了MA杂质分析 (降至0.1%) 和实时监测转化反应.

结论:

信息和通信技术介导的光策略有效地可视化和调节SSMM.
揭示了对SSMM和共结晶机制的新见解.
电荷转移共结晶显示出分子传感和动态反应监测的前景.

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