雌激素周期通过下丘脑雌激素信号调节禁食诱导的昏迷倾向
Christopher J Marshall1, Anthony E Pickering2, Michael T Ambler2
1Anaesthesia, Pain and Critical Care Research, School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, BS8 1TD, UK. chris.marshall@bristol.ac.uk.
雌激素水平影响小鼠进入麻木状态的能力,这是新陈代谢减缓的状态. 下丘脑中的雌激素受体α是这种禁食诱导的丧反应的关键.
科学领域:
- 生理学 生理学 生理学
- 神经内分泌学神经内分泌学
- 代谢调节 代谢调节 代谢调节 代谢调节
背景情况:
- 是一种生存策略,在稀缺期间涉及降低新陈代谢和体温.
- 下丘脑,特别是前视区域 (POA),在调节的过程中发挥作用.
- 众所周知,雌激素和雌醇一样,通过中央机制影响能量平衡和发热.
研究的目的:
- 为了研究雌激素信号在POA中的作用,以调解小鼠的禁食诱导的.
- 为了确定雌二醇是否调节的深度,持续时间和倾向.
主要方法:
- 在雌性小鼠的雌性性周期中监测的模式.
- 向雄性和雌性小鼠施用外源性雌醇.
- 在雌性小鼠的POA中利用ERα (雌激素受体α) 敲除.
主要成果:
- 昏迷的深度和持续时间随着期周期的变化而变化,在期达到峰值时,雌激醇水平最高.
- 外源性雌激醇在女性中延长了的发作,但在男性中没有.
- 在POA中的ERα敲击显著降低了雌性小鼠的麻.
结论:
- 在POA中通过ERα传递雌激素信号对于调节雌性小鼠的禁食诱导的丧至关重要.
- 倾向于的周期性变化可能是一个适应机制,以平衡节能和繁殖.
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