针对血管认知障碍的 Tonifying Kidney-Yang Decoction 的有效性和安全性:一个多中心双盲随机对照试验
Chun-Yan Guo1,2, Zhen-Min Xu2, Min Wang3
1Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China.
Chinese journal of integrative medicine
|February 27, 2026
概括
Tonifying Kidney-Yang Decoction (TKYD) 在血管认知障碍患者中显著改善了认知功能和神经 (脏) -阳缺乏症症状. 这种治疗在12周内证明了安全性和有效性.
科学领域:
- 综合医学是一个整体医学.
- 神经学 神经学
- 传统中国医药 传统中国医药
背景情况:
- 血管性认知障碍 (VCI) 是一个重大的健康挑战.
- 沈 (脏) - 缺乏症 (SYD) 综合征是VCI患者的常见表现.
- 评估VCI的新型治疗干预措施至关重要.
研究的目的:
- 评估Tonifying Kidney-Yang Decoction (TKYD) 对SYD综合征的VCI患者的疗效和安全性.
- 确定TKYD对认知功能和SYD相关症状的影响.
- 在严格的临床试验环境中,将TKYD与安慰剂进行比较.
主要方法:
- 这是一项多中心,双盲,随机,安慰剂对照试验,涉及120名患有SYD综合征的VCI患者.
- 参与者每天两次接受TKYD颗粒或安慰剂,持续12周.
- 主要结局包括蒙特利尔认知评估 (MoCA-BJ) 和SYD综合征量表 (SYDSS) 评分的变化.
主要成果:
- 与安慰剂 (P<0.05或P<0.01) 相比,TKYD显著改善了MoCA-BJ得分 (1.40与0.11) 并降低了SYDSS得分 (-12.17与-7.46),与安慰剂相比 (P<0.05或P<0.01).
- 在视觉空间/执行功能,定向和延迟回忆方面,TKYD显示出显著的益处.
- 迷你精神状态检查 (MMSE) 评分和神经精神症状的减少也得到了改善,没有报告任何不良事件.
结论:
- TKYD是一种有效和安全的治疗方法,用于增强SYD综合征的VCI患者的认知功能.
- TKYD对SYD核心症状产生积极影响,有助于患者的整体幸福感.
- 这项研究支持TCKYD作为这种特定患者群体的治疗选择.
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