相关实验视频
Updated: Mar 1, 2026

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
35.6K
托克斯驱动CD4+TH1效应器功能,抗瘤免疫力和自身免疫病理
Brianna Naizir1,2, Andrew C Scott3,4, Paul Zumbo5,6
1Gerstner Sloan Kettering Graduate School, Sloan Kettering Institute, New York, NY, USA. naizirb@sloankettering.edu.
Nature immunology
|February 27, 2026
概括
托克斯蛋白驱动CD4+ T辅助1细胞分化,促进抗瘤免疫和自身免疫反应. 相反,它可以反过来.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 毒素是T细胞发育和功能至关重要的核因子.
- 它在CD4+T细胞中的作用,特别是在分化和疾病中,仍然不太了解.
- 已知TOX在慢性抗原暴露期间参与CD8+T细胞耗尽.
研究的目的:
- 阐明TOX在CD4+T细胞分化中的作用.
- 研究TOX对T助手1 (TH1) 细胞表型和功能的影响.
- 探索TOX与抗瘤免疫力和自身免疫性疾病的关联.
主要方法:
- 在T细胞中获得功能和丧失功能的研究.
- 分子程序和干扰素-γ生产的分析.
- 在患者样本和疾病模型中检查TOX表达.
主要成果:
- TOX对于CD4+ TH1细胞分化至关重要,诱导TH1相关基因表达和表型.
- 在CD4+T细胞中TOX表达与癌症患者中增强的细胞毒性和抗瘤免疫力相关.
- 在自身免疫和炎症性疾病中,TOX驱动病原性反应.
结论:
- 在CD4+和CD8+T细胞中,TOX扮演着相反的角色:在CD4+T细胞中促进TH1细胞命运和抗瘤免疫力,而在CD8+T细胞中与衰竭有关.
- 托克斯是TH1细胞分化的关键调节剂,对癌症免疫疗法和自身免疫性疾病有影响.
- 准TOX可能为癌症和自身免疫性疾病提供治疗策略.
相关概念视频
T Cell Types and Functions
2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Cytotoxic T Cells-mediated Immune Response
7.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.7K
Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
T Cell Activation and Clonal Selection
16.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
16.7K
Cell-mediated Immune Responses
85.1K
Overview
85.1K
B Cell Activation and Differentiation
17.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.4K

