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Updated: Mar 1, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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在酒精使用障碍中调节内分泌系统:对临床前和人体研究的翻译系统性审查和元分析

Gabriel P A Costa1,2, Mayte A Cerezo-Matias1,2, Melissa C Funaro3

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Molecular psychiatry
|February 27, 2026
PubMed
概括

内分泌大麻素系统 (ECS) 在治疗酒精使用障碍 (AUD) 方面表现有前途. 临床前研究表明CB-1R抗剂和CBD可以减少酒精摄入量,但人类试验结果不一致,需要进一步研究.

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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Understanding the concepts of physical dependence,...
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