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怀孕前,怀孕期间和怀孕后的绿色空间暴露与后代自闭症谱系障碍之间的关联

Bethsaida Cardona¹, Hayon Michelle Choi², Kristen Lyall³

¹Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Journal of exposure science & environmental epidemiology

|February 27, 2026

概括

怀孕期间接触绿色空间,特别是在头三个月,与儿童患自闭症谱系障碍 (ASD) 的风险降低有关. 这一发现强调了绿色环境对母亲和儿童健康的重要性.

科学领域:

环境健康环境健康
发育儿科发育儿科
流行病学流行病学

背景情况:

怀孕期间的绿色空间暴露可能会影响自闭症谱系障碍 (ASD) 风险.
现有的研究是有限的,但表明了潜在的保护作用.
了解这种关联可以为公共卫生策略提供信息.

研究的目的:

调查怀孕期间绿色空间暴露与ASD风险之间的关联.
为了确定在怀孕前,怀孕和产后期间敏感性的关键窗口.
评估接近绿色环境对后代神经发育的影响.

主要方法:

在护士健康研究II队列中进行了一个嵌套的病例控制研究.
确定了ASD病例 (n=245) 和匹配的对照 (n=1526).
在270米和1230米的缓冲区内,使用基于卫星的规范差异植被指数 (NDVI) 测量了绿地暴露.

主要成果:

在怀孕的第一季度,在270米的缓冲区内增加绿色空间暴露与ASD的几率降低25%有关.
在头三个月内,NDVI的四分位数间范围增加显示出显著的反向关联 (OR=0.75).
对于其他暴露期或1230m缓冲区,没有发现显著的关联.

结论:

第一个三个月的绿色空间暴露与自闭症谱系障碍风险相反相关.
这一发现表明,头三个月是绿色空间效益的关键时期.
城市规划和设计应该考虑增加对绿色空间的访问,以获得潜在的神经发展益处.

关键词:

流行病学流行病学绿色空间 (green space) 是一个绿色空间.孕产妇和胎儿的暴露/健康神经发育神经发育易受伤害的人群易受伤害的人群

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