无利法米,化物和乙醇的组合,用于治疗Mycobacterium avium复杂的肺病
G D Boorgula1, A Shrivastava1, S Singh1
1Divison of Infectious Diseases, Department of Medicine, School of Medicine, University of Texas at Tyler, Tyler, TX, USA.
概括
对Mycobacterium avium复合体 (MAC) 肺部疾病需要新的多种药物组合. 基于米诺环素的疗法表现有前途,为改善MAC治疗结果提供了标准疗法的潜在替代方案.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对Mycobacterium avium复合体 (MAC) 肺部疾病的基于指导方针的治疗具有低于最佳的持续唾液培养转化率.
- 对于新型和改进的多种药物组合来有效治疗MAC肺部疾病,有极大需求.
研究的目的:
- 评估八种不同的药物对MAC的体外疗效.
- 确定潜在的新型口服多药组合治疗MAC肺部疾病,包括没有利法素,化物和乙醇的选择.
主要方法:
- 对8种药物进行了最低抑制度 (MIC) 实验,针对ATCC#700898菌株和49种临床MAC分离物.
- 进行了单药和多药组合研究,以评估药物协同作用和对抗作用.
主要成果:
- MIC90值有显著的差异,贝达基林 (0.25 mg/L) 是最强效的,其次是利法布丁 (4 mg/L),利法 (16 mg/L),泰迪索利德 (16 mg/L),乙ambutol (128 mg/L) 和米诺基克林 (128 mg/L).
- 米诺环素与阿齐思罗米和乙醇结合时表现出协同效应,与单独治疗相比,显著增强了MAC杀伤.
- 新的口服组合,如阿兹特罗米-米诺环素-泰迪索利德和特比-泰迪索利德-米诺环素,显示出有前途的MAC杀死,而贝达基林的添加后者建议对抗.
结论:
- 通过体外测试,通过体外测试确定了几种不含利法素,化物和乙醇的口服多种药物组合.
- 基于米诺环素的疗法显示出显著的潜力,需要进一步进行临床前和临床研究来治疗MAC肺部疾病.
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