蒙特卡洛研究关于怀孕期间碳束骨辐射的胎儿剂量评估
Ji Won Choi1, Yongdo Yun2, Se Hyung Lee3,4
1Department of Radiation Convergence Engineering, Yonsei University, Wonju, Republic of Korea.
Medical physics
|February 28, 2026
概括
这项研究估计了怀孕期间碳束骨辐射 (CSI) 产生的胎儿器官剂量. 胎儿剂量因妊娠年龄而异,在晚期增加,为接受碳治疗的孕妇癌症患者提供了关键数据.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 放射疗法是一种放射治疗.
背景情况:
- 放射治疗是孕妇癌症患者的选择,当治疗不可避免时.
- 在孕妇放射治疗期间,尽量减少胎儿剂量至关重要.
- 在成功的质子疗法病例之后,碳疗法是孕妇脊辐射 (CSI) 的潜在替代方案.
研究的目的:
- 为了调查和量化胎儿的器官剂量导致碳束CSI在怀孕期间.
- 将碳束CSI的胎儿器官剂量与质子束治疗的剂量进行比较.
主要方法:
- 使用了高质量的孕妇幻影,代表了八个妊娠年龄 (8-38周).
- 使用TOPAS MC执行蒙特卡洛剂量计算,使用碳CSI的规定的RBE加权剂量为36 Gy.
- 计算了28个放射敏感胎儿器官的吸收剂量,并将它们与质子疗法数据进行了比较.
主要成果:
- 胎儿器官剂量在妊娠年龄之间表现出差异,最高剂量范围在35周 (13.2-88.3mGy) 和最低在8周 (21.0-30.3mGy).
- 胎儿全身剂量最初从怀孕早期到怀孕中期减少,但由于胎儿的生长和接近光束,在晚期增加.
- 在不同胎儿器官中观察到剂量变化,突出显示了精确准的重要性.
结论:
- 这项研究提供了第一次专门估计妊娠期间碳疗法对胎儿的剂量.
- 这些发现具有临床信息,用于评估怀孕癌症患者与碳束CSI相关的风险.
- 结果支持在接受碳治疗的孕妇中进行放射治疗的知情决策.
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