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Updated: Mar 1, 2026

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
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在β细胞中MANF表达的升高通过减弱小岛应激和免疫性来保护小鼠免受链毒素诱导的糖尿病

Huini Li1, Tatiana Danilova1, Erik Palm1

  • 1Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 28, 2026
PubMed
概括

介脑星细胞衍生神经营养因子 (MANF) 通过减少β细胞应激和免疫攻击来预防1型糖尿病. 在贝塔细胞中过度表达MANF可以改善小鼠的葡萄糖控制和小岛健康.

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