遗传风险和身体活动与发生型2型糖尿病的关联
Xuan Zhou1, Germán D Carrasquilla1, Malene R Christiansen1
1Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
每日步数和2型糖尿病的遗传风险有显著的相互作用. 增加体力活动可以帮助减轻对2型糖尿病的遗传倾向,特别是在高风险人群中.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 代谢疾病 代谢疾病
- 预防医学 预防医学
背景情况:
- 2型糖尿病是一个日益严重的全球健康问题.
- 遗传倾向对2型糖尿病的发展起着重要作用.
- 身体活动是影响2型糖尿病风险的已知可修改因素.
研究的目的:
- 研究每日步数 (体育活动) 与基因风险在预测2型糖尿病中的相互作用.
- 确定身体活动是否会改变遗传倾向对2型糖尿病风险的影响.
主要方法:
- 对来自"我们所有人"研究计划的9,501名参与者的分析.
- 使用可穿戴设备的每日步数来量化身体活动.
- 通过全球多基因分数评估遗传风险.
- 使用电子健康记录识别发生的2型糖尿病.
- 考克斯比例危险模型的应用和因相互作用而导致的相对过度风险 (RERI) 进行统计分析.
主要成果:
- 低身体活动和高遗传风险 (18.4/1000人年) 的人群中,2型糖尿病发病率最高.
- 观察到身体活动和遗传风险之间存在显著的附加相互作用 (RERI = 0.20,P = .007).
- 大约有15%的2型糖尿病风险过剩归因于这种相互作用.
结论:
- 证据支持基因风险和体力活动在2型糖尿病发展中的附加相互作用.
- 整合基因组和可穿戴设备数据可以识别那些可能从增加体力活动中获益最多的人.
- 身体活动是减轻基因影响的2型糖尿病风险的关键可修改因素.
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