细胞因子和生长因子由人体氨基细胞产生和释放:从共同培养和奥米克研究中吸取教训
Stephane Esnault1,2,3, Arnaud Dendooven1,2, Emeline Delaunay1,2
1Univ. Lille, INSERM, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000, Lille, France.
Journal of leukocyte biology
|February 28, 2026
概括
人类乙酸细胞释放有毒的蛋白质和介质,影响免疫反应和组织重塑. 这一审查证实了它们通过分泌的细胞因子和生长因子作为效应细胞的作用,影响其他细胞类型.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 组织重塑 组织重塑
背景情况:
- 人类乙氨基基基因被称为有毒颗粒蛋白,Charcot-Leyden晶体,DNA陷和白血.
- 它们在免疫反应和通过细胞因子和生长因子释放的组织重塑中的作用尚未完全理解.
研究的目的:
- 审查关于人类氨基酸共培养的文献,以确定分泌的细胞因子和生长因子.
- 为了确定这些乙酸酶衍生媒介在其他细胞类型上的功能.
- 通过转录组数据来确认这些因子的乙素表达.
主要方法:
- 关于涉及人类乙氨基和其他细胞类型 (上皮细胞,纤维细胞,淋巴细胞,内皮细胞) 的培研究的文献综述.
- 对共同培养模式的分析:直接接触,过器分离和条件介质.
- 检查已发表的人类乙氨基转录组数据集.
主要成果:
- 共同培养模型识别出潜在的细胞因子和生长因子,这些因子是由影响其他细胞类型的埃索诺菲尔分泌的.
- 转录组数据证实了这些因素在人体血液和组织中表达.
- 还确定了其他可能重要的异类产品.
结论:
- 人类乙酸细胞通过释放有毒蛋白质 (例如EPX,ECP,MBP),甲状腺蛋白-10,DNA和白细胞蛋白) 作为效应细胞起作用.
- 乙氨基酸细胞产生和释放细胞因子和生长因子,调节它们的细胞环境.
- 这一综述支持了氨基酸在免疫和组织过程中的多方面的作用.
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