不确定阶段的乙型肝炎患者的患病率,临床表现和结果:系统性审查和元分析
Jie Li1,2, Xiaoming Xu3, Jiacheng Liu1
1Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
近40%的慢性乙型肝炎 (CHB) 患者进入不确定的阶段,缺乏明确的免疫分类. 这些患者面临肝细胞癌和肝脏相关不良结果的风险,需要进一步研究量身定制的治疗方法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 目前的慢性乙型肝炎 (CHB) 准则定义了不同的免疫阶段.
- 很大一部分CHB患者不符合这些分类,存在于"不确定的阶段".
研究的目的:
- 系统地评估不确定阶段的CHB患者的患病率,临床表现和结果.
- 根据美国肝脏疾病研究协会 (AASLD) 2018年和欧洲肝脏研究协会 (EASL) 2017年指导方针,分析不确定的CHB患者.
主要方法:
- 进行了元分析,从创建到2024年8月21日搜索了四个数据库.
- 根据AASLD 2018或EASL 2017指南,报告了50项根据AASLD 2018或EASL 2017指南报告不确定的CHB患者的研究.
主要成果:
- 不确定的CHB患者的患病率根据AASLD 2018指南约为38.9%,根据EASL 2017指南为38.8%.
- 在不确定的CHB患者中,肝细胞癌的综合发病率约为每1000人年约5.3,对于肝脏相关事件,它约为每1000人年7.3-9.8,这取决于使用的指南.
结论:
- 不确定的阶段影响近40%的CHB患者.
- 这些患者有患肝细胞癌和与肝脏有关的不良结果的风险.
- 进一步的研究至关重要,以制定特定的治疗策略,为不确定的CHB患者.
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