在体外受精-胚胎移植中解决多胎妊娠问题:当前情况,挑战和解决方案
Xi Wu1, Yu Liang1, Xiaoling Yang1
1Reproductive Center the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
概括
由于单个胚胎移植 (SET) 的成功率较低,体外受精-胚胎移植 (IVF-ET) 的多胎妊娠仍然很高. 改进胚胎评估技术是提高SET有效性和减少多胎出生的关键.
科学领域:
- 生殖医学 生殖医学
- 生物技术是生物技术.
- 临床伦理学 临床伦理学
背景情况:
- 不孕率的上升和IVF-ET的使用增加,导致多胎妊娠的高发病率.
- 多胎妊娠对母亲和婴儿的健康构成重大风险.
- 在IVF-ET实践中的区域差异,特别是单胚胎移植 (SET) 采用,影响多胎妊娠率.
研究的目的:
- 对IVF-ET中多胎妊娠的现状,原因和解决方案进行全面审查.
- 分析阻碍SET普及的挑战.
- 探索改善胚胎评估和SET成功的技术进步.
主要方法:
- 对IVF-ET和多胎妊娠的临床,伦理和技术研究进行系统审查.
- 对影响单胚移植 (SET) 和双胚移植 (DET) 之间的选择因素的分析.
- 评估新兴技术,以评估胚胎发育潜力.
主要成果:
- 在全球范围内,IVF-ET中的多胎妊娠率仍然很高,与SET采用相关的显著差异.
- 偏爱DET而不是SET的原因是SET的临床怀孕率 (CPR) 历史较低.
- 有前途的技术包括人工智能集成的时隔成像和胚胎评估的先进分子技术.
结论:
- 提高胚胎发育潜力评估的准确性对于克服SET与DET困境至关重要.
- 人工智能和分子生物学方面的进步有望提高SET成功率.
- 需要对新技术进行标准化实践和多中心验证,以减少与IVF-ET相关的多胎妊娠.
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