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单边和双边语音噪音听力状况与痴呆症的关联

Haoxiang Lang^1,2, Zirong Ye^1,3, Xiaoman Wang⁴

¹Department of Neurology, Fujian Institute of Geriatrics, Union Hospital of Fujian Medical University, Fuzhou, China.

International journal of geriatric psychiatry

|February 28, 2026

概括

双边听力损失,特别是在语音噪音 (SIN) 任务中,会增加痴呆症的风险. 听力保护应针对侧向性和严重程度,以精确预防痴呆症.

科学领域:

神经科学是一个神经科学.
听力学听力学是指听力学.
公共卫生公共卫生

背景情况:

听力损失是已知的痴呆症风险因素,但中央听力处理缺陷 (语音噪音,SIN) 尚未得到研究.
认知储备 (CR) 可能会影响听力损失和痴呆风险之间的关系.

研究的目的:

调查双边SIN听力损失与所有原因痴呆风险之间的关联.
为了检查认知储备 (CR) 是否会改变SIN听力损失对痴呆风险的影响.

主要方法:

使用英国生物库数据 (N=72,004) 的前性队列研究,后续研究至2023年10月.
考克斯的比例风险模型评估了与SIN听力状况和CR相关的痴呆风险和大脑体积变化.
分析包括了SIN听力和CR之间的相互作用.

主要成果:

双边 (HR=1.507) 和单边 (HR=1.181) 听力损失都与痴呆风险增加有关.
双边听力损失与听觉和记忆相关区域 (海马,腹) 的大脑体积减少有关.
没有发现CR对SIN听力-痴呆症关联有显著的缓解效应.

结论:

双边听力状况显著影响痴呆风险和大脑体积.
听力保护策略应纳入侧向性和严重性,以有针对性的预防痴呆症.

关键词:

英国生物银行.双边特定的语音在噪音中的听觉.大脑体积大脑体积的大脑体积队列研究是指队列研究.痴呆症痴呆症是一种痴呆症.效果修改器效果修改器

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