超白细胞症是否可能由非血液学状况引起? 一个10年后期的第三级护理中心队列研究
Elisavet Moutzouri1, Emmanuel Häfliger1, Katarzyna Aleksandra Jalowiec1
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Annals of medicine
|February 28, 2026
概括
超白细胞症 (HL),高白细胞计数,通常是由于血液癌症. 非血液学原因很少见,通常与先进的固体瘤有关,需要进一步调查.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 超白细胞症 (HL) 被定义为白细胞计数超过100G/L.
- HL通常与血液性恶性瘤有关.
- HL的非血液学原因还没有得到充分的研究.
研究的目的:
- 描述超白细胞瘤的非血液学原因.
- 分析成人患者HL的流行和性质.
主要方法:
- 从2013年到2023年,对成年患者病历进行回顾性分析.
- 查超白细胞症的病例.
- 专注于识别非血液病的病因.
主要成果:
- 在285名HL患者中,97%患有血液恶性瘤 (例如慢性淋巴细胞白血病,淋巴瘤,AML,CML).
- 非血液学原因占病例的3%,主要与先进的固体瘤和副瘤综合征有关.
- 在这个队列中没有观察到与感染相关的单独HL病例.
结论:
- HL强烈表明了潜在的血液性恶性瘤.
- 一小部分HL病例源于非血液学原因,特别是晚期固体瘤.
- 立即的外周血液涂抹检查和血液学咨询对于HL诊断至关重要.
相关概念视频
Disorders of Leukocytes
2.1K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.1K
Structure and Function of Leukocytes
4.8K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
4.8K


