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Updated: Mar 1, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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由抗Z-DNA抗体介导的B-to-Z DNA转换的结构基础

Cheng-Chung Lee1,2, Shu-Fang Hsu1, Ya-Wen Chang1

  • 1The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110301, Taiwan.

Nucleic acids research
|February 28, 2026
PubMed
概括

这项研究揭示了抗体如何稳定Z-DNA,这种左撇子DNA形式对各种生物过程至关重要. Z22抗体片段 (cZ22-Fab) 通过脊柱追踪结合Z-DNA,提供对DNA构造和疾病机制的见解.

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