患有白质超强度的个体的休息状态功能连接性改变:基于网络的统计学研究
Kunpeng Cheng1,2, Rui Qin1,2, Xin Wang3
1Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, 230601 Hefei, Anhui, China.
Journal of integrative neuroscience
|February 28, 2026
概括
白质超强度 (WMHs) 与大脑连接的改变有关,影响认知功能. 这些功能网络变化可能成为认知衰退的早期生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 白质过强度 (WMHs) 是大脑小血管疾病的关键指标.
- WMHs与认知能力下降有很强的联系.
研究的目的:
- 研究WMHs患者的全球功能网络变化.
- 探索这些网络变化与认知功能之间的关联.
主要方法:
- 使用了静止状态功能磁共振成像 (RSFC) 和基于网络的统计数据 (NBS).
- 蒙特利尔认知评估 (MoCA) 评分在33名WMH和34名对照人群之间进行了比较.
- 支持矢量机 (SVM) 模型评估了功能网络的诊断潜力.
主要成果:
- 患有WMH的个体在包括DMN-SMN,DMN-CON和CON-CER在内的网络中MoCA得分较低,RSFC减少.
- 在基于网络连接的基础上,SVM模型在分类WMH状态方面显示出高准确度 (AUC>0.82).
- 全球和模块化RSFC强度与MoCA分数正相关.
结论:
- WMH与广泛的功能连接性改变有关,特别是在认知和运动网络中.
- 这些RSFC差异可能是WMH患者认知衰退的基础.
- 改变的功能网络显示为早期检测和干预的生物标志物具有前途.
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