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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
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在随机条件下的间接流感疫苗有效性:系统性审查和元分析.

Andrew C Gilmore1, Yuanyuan Liang1, Ian M Galbreath1

  • 1Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W. Baltimore St., Baltimore, Maryland, 20201, USA.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
|February 28, 2026
PubMed
概括

高质量的流感间接疫苗有效性 (IVE) 证据有限. 这项系统性审查发现,虽然直接疫苗的有效性是中等的,但间接疫苗的有效性是低的,这表明个人接种疫苗是预防流感的最可靠方法.

关键词:
接种流感疫苗可以预防流感.进行元分析分析.疫苗的间接有效性 疫苗的间接有效性随机对照试验是随机对照试验.疫苗的有效性 疫苗的有效性

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科学领域:

  • 流行病学 流行病学
  • 公共卫生 公共卫生
  • 传染性疾病 传染性疾病

背景情况:

  • 间接疫苗有效性 (IVE) 估计容易产生偏见,流感的高质量证据有限.
  • 随机对照试验 (RCT) 为评估IVE提供了一个强大的方法.

研究的目的:

  • 系统地审查和对RCT进行元分析,以估计IVE流感.
  • 在随机条件下提供可测量的IVE的严格基准.

主要方法:

  • 在2025年12月9日之前发表的RCT的系统审查和元分析.
  • 在MEDLINE和EMBASE搜索了非机构环境中的英语RCT.
  • 包括试验比较RT-PCR确认的疫苗接种与未接种疫苗的家庭或社区的流感疾病.

主要成果:

  • 包括12个具有偏差风险低的RCT (十个集群随机化,两个个体随机化).
  • 集中的直接疫苗有效率 (DVE) 为44.1% (95% CI:29.6%,55.6%).
  • 综合的IVE为13.7% (95% CI:1.5%,24.5%),大多数试验没有显示出统计学上显著的间接影响.

结论:

  • 本次审查为流感IVE建立了一个方法上健全的基准.
  • 聚合的IVE明显低于DVE,表明社区对疫苗接种的保护有限.
  • 个人接种疫苗仍然是预防流感的最可靠策略,而不是依赖社区层面的影响.