相关实验视频
Updated: Mar 1, 2026
06:55
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
10.0K
台湾的乳杆菌通过调节皮质代谢来抑制胆结石的形成
Tianming Liu1, Haoran Ding1, Zhenyi Lv1
1The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Current microbiology
|February 28, 2026
概括
肠道微生物群影响胆结石的形成. 补充Lactobacillus taiwanensis通过增加Lipoxin A4 (LXA4) 水平来降低胆结石发病率,提供一种潜在的治疗方法.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 已知肠道微生物群通过肠肝轴在胆结石形成中的作用.
- 在胆结石发育过程中,胆结石微生物群的特定变化和功能需要进一步研究.
研究的目的:
- 研究消化道微生物群落对胆结石形成的影响.
- 阐明基底作用的机制,以叶叶微生物群对胆结石的影响.
主要方法:
- 通过在小鼠体质生态饮食和正常饮食中进行元基因组测序,对体和结肠微生物群进行比较分析.
- 建立了Lactobacillus taiwanensis的测量和Lipoxin A4 (LXA4) 腹腔内注射模型.
- 分析胆结石发病率,肝/胆 NETs,LXA4水平,以及通过西部斑块,ELISA和代谢学来分析胆结石发病率.
主要成果:
- 在形成胆结石和对照组之间观察到肠道微生物群组成的显著差异.
- 石化饮食降低了小肠中的Lactobacillus taiwanensis的丰富性;其管理减少了胆结石的发生率.
- 台湾乳杆菌增加了LXA4水平,降低了肝/胆 NETs的调节,并抑制了胆结石的形成.
结论:
- 皮质和结肠微生物群对胆结石形成表现出特定地点的影响.
- 台湾的乳酸菌可以通过调节乳腺代谢和LXA4生产来抑制胆结石.
- 台湾的乳酸菌为预防和治疗胆结石提供了潜在的治疗策略.
相关概念视频
01:21Drugs for Treatment of Constipation-Predominant IBS
1.0K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.0K
01:40Hormonal Regulation
49.0K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
49.0K
01:17Gastritis-II: Pathophysiology
1.5K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.5K