Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mitochondrial Membranes01:45

Mitochondrial Membranes

17.5K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.5K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

498
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
498
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.3K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

817
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
817
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.6K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.6K
Mitochondria01:37

Mitochondria

21.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

SAVE: Spectrum-Aided Visual Enhancement for AI-Based Skin Cancer Detection.

Diagnostics (Basel, Switzerland)·2026
Same author

Integrative Transcriptomic and Proteomic Profiling Identifies S100P as a Potential Functional Biomarker for Sessile Serrated Lesions.

Digestive diseases and sciences·2026
Same author

From surface to signal: Clinical pathways for transition metal dichalcogenide-based electrochemical biosensors.

Biosensors & bioelectronics·2026
Same author

Real-world comparative outcomes of atorvastatin, rosuvastatin, and lovastatin-niacin fixed-dose combination in metabolic dysfunction-associated steatotic liver disease: hepatic, metabolic, and economic perspectives.

Diabetology & metabolic syndrome·2026
Same author

Machine-learning prediction of 30-day infection-related hospitalization in advanced CKD.

BMC infectious diseases·2026
Same author

Efficacy of Spectral-Aided Visual Enhancer in Classification of Esophageal Cancer.

Cancers·2026
Same journal

Network toxicology deciphers micro- and nanoplastics-mediated mixture hazard, predictive risk assessment, and regulatory translation.

Archives of toxicology·2026
Same journal

Scientific approach to derive occupational exposure limits for formaldehyde releasers.

Archives of toxicology·2026
Same journal

Molecular dosimetry of hemoglobin adducts in mice exposed to ethylene oxide.

Archives of toxicology·2026
Same journal

From data mining to mechanistic prediction: a study on drug-induced lung injury integrating FAERS, machine learning, and network toxicology.

Archives of toxicology·2026
Same journal

Copper oxide nanoparticles: from EU-regulatory landscape and mechanistic toxicity towards a cuproptosis-linked adverse outcome pathway.

Archives of toxicology·2026
Same journal

Causality analysis of toxicological mechanisms in networked systems such as adverse outcome pathway networks.

Archives of toxicology·2026
查看所有相关文章

相关实验视频

Updated: Mar 1, 2026

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.6K

微塑料诱导线粒体功能障碍,加速心血管病原发生.

Tsung-Hsien Chen1, I-Tseng Chu2, Rei-Yeuh Chang2

  • 1Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan.

Archives of toxicology
|February 28, 2026
PubMed
概括
此摘要是机器生成的。

微塑料和纳米塑料 (MNP) 通过破坏线粒体引起心血管疾病. 了解这种联系可能有助于预防环境健康风险.

关键词:
动脉样硬化是一种动脉样硬化.心血管系统的心血管系统微塑料是一种微塑料.线粒体中的线粒体.纳米塑料是一种纳米塑料.氧化应激是一种氧化应激.

更多相关视频

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.5K
Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

9.7K

相关实验视频

Last Updated: Mar 1, 2026

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

8.6K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.5K
Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells
06:15

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

9.7K

科学领域:

  • 环境健康 环境健康
  • 毒理学 毒理学 毒理学
  • 心血管科学 心血管科学

背景情况:

  • 微塑料和纳米塑料 (MNP) 是普遍存在的环境污染物.
  • 越来越多的证据将MNP与全身毒性联系在一起,包括心血管影响.
  • 在人体组织中发现MNP,引发了健康问题.

研究的目的:

  • 审查MNP引发心血管损伤的机制.
  • 探索线粒体功能障碍在与MNP相关的心血管病变发生中的作用.
  • 检查性别特异性反应和发育因素.

主要方法:

  • 文献综述整合机械学的见解.
  • 分析MNP对线粒体完整性,氧化应激和信号传递的影响.
  • 检查MNP对炎症,衰老,髓和血管重塑的影响.

主要成果:

  • MNPs损害了线粒体功能,诱导氧化应激,并破坏心脏组织中的信号传递.
  • MNPs促进了基因组的不稳定性,炎症,细胞衰老和髓功能障碍.
  • MNPs有助于亲动脉样硬化重塑,并显示性别特异性影响.

结论:

  • 通过线粒体损伤,MNP暴露对心血管健康构成重大风险.
  • 了解MNP和线粒体之间的分子相互作用对于开发干预措施至关重要.
  • 减轻环境心血管风险需要解决MNP污染及其生物影响.