经典的霍奇金淋巴瘤与埃普斯坦-巴尔病毒在治疗性结肠炎的vedolizumab治疗期间的重新激活相关
Tatsuya Hasegawa1, Masatsugu Kojima2, Toru Miyake1
1Department of Surgery, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga, 520 2192, Japan.
Clinical journal of gastroenterology
|February 28, 2026
概括
爱斯坦-巴尔病毒相关的霍奇金淋巴瘤是治疗维多利祖马布的性结肠炎患者的罕见并发症. 这一案例凸显了在UC患者中考虑EBV相关肠道淋巴瘤的重要性,这些患者在治疗期间有持续的胃肠道问题.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 接受免疫抑制治疗的炎症性肠病 (IBD) 患者有患埃普斯坦-巴尔病毒 (EBV) 相关淋巴增殖性疾病的风险.
- 经典的霍奇金淋巴瘤 (cHL) 在治疗性结肠炎 (UC) 的vedolizumab期间发展非常罕见.
研究的目的:
- 报告一种极为罕见的EBV相关的肠道cHL病例,该病例发生在用vedolizumab治疗的UC患者身上.
- 为了提高临床医生对这种潜在并发症的认识.
主要方法:
- 一名73岁的女性患有类固醇依赖性UC,此前接受过阿扎西奥普林治疗,目前接受维多利祖马布治疗,呈现出持续性血液.
- 结肠镜检查显示了结肠病变,随后进行了腹腔镜全肠直肠切除术.
- 手术样本的组织病理学检查确定了与EBV相关的cHL.
主要成果:
- 手术样本证实了与EBV相关的cHL,里德-斯特恩伯格细胞对CD20,CD30,PD-L1和EBV编码RNA呈阳性.
- 该患者有UC病史,并接受了31个月的vedolizumab治疗.
- 由于同时治疗乳腺癌,避免使用其他系统性免疫抑制剂.
结论:
- 虽然多因素,EBV相关的肠道cHL的发展应该考虑在UC患者Vedolizumab呈现与瘤类或壁面加厚.
- 临床医生必须保持对这种患者群体中罕见并发症 (如EBV相关的cHL) 的高度怀疑指数.
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