肠道微生物群和代谢健康:从失生症到治疗方法
Sabitha Sasidharan Pillai1,2, Ambika P Ashraf3
1Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, USA. sabithas99@gmail.com.
概括
肠道微生物群失生症破坏宿主新陈代谢,并导致肥胖和糖尿病. 通过个性化干预恢复微生物平衡是未来代谢健康管理的关键.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 肠道微生物组研究研究
背景情况:
- 肠道微生物群 (GM) 显著影响宿主新陈代谢,并与肥胖,2型糖尿病 (T2D) 和代谢综合征 (MS) 有关.
- 肠道微生物失调症的特点是转基因组合和功能的改变,通过各种途径导致代谢功能障碍.
- 失生症会影响能量提取,肠道屏障完整性,炎症和神经免疫信号,影响整体代谢平衡.
研究的目的:
- 审查当前关于肠道微生物群失调和其在代谢功能障碍中的功能作用的证据.
- 检查细菌,病毒和真菌中的失生菌对代谢健康的影响.
- 评估针对肠道微生物群的各种治疗策略的临床准备和有效性.
主要方法:
- 文献综述综合了关于肠道微生物群失调和代谢疾病的证据.
- 分析将失生症与代谢功能障碍联系在一起的途径,包括能量提取,屏障完整性,炎症和昼夜节律.
- 对肠道微生物群调节的现有和实验性疗法的评估,如饮食,益生菌,益生菌和便微生物群移植.
主要成果:
- 肠道失调有助于通过增强的能量收获,损害肠道屏障,元炎症和扰乱昼夜/神经免疫信号的代谢功能障碍.
- 肠道病毒和真菌生物群的变化,以及细菌失生症,可以加剧代谢风险和炎症.
- 已建立的代谢疗法 (例如GLP-1激动剂,减肥手术) 对转基因产生影响,但直接微生物疗法在人体试验中显示出不同的结果.
结论:
- 肠道微生物群失生症是代谢疾病的重要因素,影响多种生理途径.
- 针对肠道微生物群的治疗策略是有前途的,但需要进一步改进以获得一致的有效性.
- 个性化微生物组学,利用人工智能和精确干预,代表了量身定制的代谢管理的未来.
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