perfluoroalkyl物质与红细胞的异构体特定的结合亲和力
Jianli Qu1, Tian Xia1, Haomiao Yu1
1College of Environmental Science and Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou, Zhejiang 310018, PR China.
和多醇基物质 (PFASs) 与红细胞 (RBCs) 结合,更长链的PFASs表现出更高的亲和力. 这项研究澄清了PFAS与血液成分的相互作用,这对于了解它们在人体中的命运至关重要.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 和多醇基物质 (PFAS) 是人类血液中广泛存在的环境污染物.
- 虽然已知PFAS与血清蛋白的相互作用,但它们与红细胞 (RBC) 的结合不明.
研究的目的:
- 调查各种PFAS对老鼠和人类红细胞 (RBC) 的异构体特定结合亲和力.
- 通过固定人工膜 (IAM) 染色学来评估PFASs对红细胞膜的异构体特定吸附.
主要方法:
- 化大鼠和人类红细胞, PFAS 度不同.
- 使用IAM染色学测量异构体特定的结合亲和力 (Fr) 和吸附 (KIAM).
主要成果:
- 线性 perfluoroalkyl carboxylates (PFCAs) 显示,随着链条长度的增加,与红细胞的结合亲和力增加.
- 与 perfluorooctane sulfonate (PFOS) 和 perfluorobutane sulfonate (PFBS) 相比, perfluorohexane sulfonate (PFHxS) 的红血细胞亲和力较低.
- 分支PFAS异构体表现出比它们的线性对应物更弱的结合,PFOSA显示出比PFOS更高的亲和力.
结论:
- PFAS与红细胞结合是异构体特异的,并受到链条长度和结构的影响.
- 这项研究为了解血液成分中的PFAS的行为和分布提供了关键数据.
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