耐性粉-羊角酸通过保护肠道微生物群屏障和抑制炎症反应,有效改善脂聚糖诱导的抑郁行为
Yining Yang1, Yuanyuan Lv2, Ziqian Liang2
1College of Animal Medicine, Sichuan Agricultural University, Yaan, China.
Journal of food science
|February 28, 2026
概括
通过耐性粉输送的酸通过调节肠道微生物群和神经炎症来缓解小鼠的类似抑郁的行为. 这种饮食干预措施有望通过恢复肠道健康和大脑功能来管理抑郁症.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群,免疫和神经炎症都与抑郁症的发病有关.
- 脂肪酸具有神经保护性质.
研究的目的:
- 为了研究通过耐性粉输送的酸对小鼠LPS诱导的类似抑郁行为的影响.
- 阐明潜在的机制,包括肠道微生物群调节和神经炎症调节.
主要方法:
- 雄性ICR小鼠接受了50天的耐性粉-酸复合物 (RS-FA) 治疗.
- 使用脂聚糖胺 (LPS) 注射诱导了一个抑郁模型.
- 进行了行为测试 (TST,OFT),生物化学分析 (TNF-α,5-HT),组织学检查和16S rRNA测序.
主要成果:
- 在小鼠中,RS-FA预治疗显著减少了类似抑郁症的行为.
- RS-FA降低了血清TNF-α水平,并增加了海马5-HT水平.
- 组织学分析显示,结肠和海马的损伤有所改善.
- 16S rRNA分析显示RS-FA逆转了LPS诱导的肠道失生症,增加了有益细菌,并提高了短链脂肪酸水平.
- RS-FA调节了TLR4/NF-κB和托的代谢途径.
结论:
- 通过耐性粉输送的羊角酸显示出类似抗抑郁药的效果.
- 该机制涉及恢复肠道微生物群平衡,减少神经炎症和调节关键信号通路.
- 这种方法通过准肠-大脑轴,为抑郁症提供了潜在的治疗策略.
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