了解皮肤感官综合征:诊断挑战和治疗影响
Janmesh D Patel1, Mohammad Jafferany2
1University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Clinical and experimental dermatology
|February 28, 2026
概括
皮肤感觉综合征 (CSS) 涉及来自神经功能障碍的和疼痛. 本综述提供了通过整合病理生理学和实际治疗策略来诊断和管理这些复杂的皮肤疾病的路线图.
科学领域:
- 皮肤病学和神经病学
- 神经科学是一个神经科学.
- 心理皮肤学 心理皮肤学
背景情况:
- 皮肤感官综合征 (CSS) 是各种疾病,在看似正常的皮肤上引起,灼热和疼痛.
- 这些综合症具有共同的潜在机制,包括小纤维神经功能障碍,中央敏感化和神经免疫相互作用.
- - 划痕循环是CSS的一个关键延续因素.
研究的目的:
- 综合当前对CSS病理生理学和管理的理解.
- 为评估和治疗成人七种常见的CSS类型提供一个实际的框架.
- 将神经生物学概念与临床实践相结合,以改善患者的治疗结果.
主要方法:
- 对CSS的当前概念和管理策略进行叙述性审查.
- 从外围神经到中央处理的病理生理学的详细概述.
- 实用性评估框架包括病史,症状映射和有针对性的调查.
- 根据疾病类型,严重程度和精神皮肤学方法的整合组织的管理策略.
主要成果:
- 一种临床专注的病理生理学,整合了外周,脊柱和脊柱上机制,包括大脑-皮肤轴和自主影响.
- 一个务实的评估框架,强调有针对性的病史,症状映射,红旗和选择性诊断测试.
- 管理策略包括教育,触发器修饰,局部和系统神经调节剂以及精神皮肤学整合.
- 针对疾病的具体指导,包括初步步骤和耐火病例的辅助.
结论:
- 本综述提供了一个基于机制的路线图,用于诊断和管理CSS.
- 更好的理解和综合治疗方法可以提高患者咨询和结果.
- CSS管理需要采用多学科的方法,应对外围,中心和心理因素.
相关概念视频
Sensory Functions of the Skin
8.9K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
8.9K
Overview of Somatic Sensory Pathways
9.0K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
9.0K
Skin Diseases and Disorders
5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
532
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
532
Somatosensation
44.0K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
44.0K
Changes in Skin Color: Clinical Perspectives
4.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.0K


